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Research ArticleDOI Number : 10.36811/jca.2021.110036Article Views : 0Article Downloads : 1
Effect of Tramadol on Hormones and Lipid Peroxidation of male Rabbits
Eman, G. A. Allafi1, Om-alsaad E. I. Omar1 and Fayrouz. A. Khaled2
1Biochemistry Department, Faculty of Medicine, Omar Al-Mokhtar University, El -Beida-Libya
2Chemistry Department, Faculty of Science, Omar Al-Mokhtar University, El -Beida-Libya
*Corresponding Author: Fayrouz. A Khaled, Chemistry Department, Faculty of Science, Omar Al-Mokhtar University, El -Beida-Libya, Email: fayalzobair@yahoo.com
Article Information
Aritcle Type: Research Article
Citation: Eman, G. A. Allafi, Om-alsaad E. I. Omar, Fayrouz. A. Khaled. 2021. Effect of Tramadol on Hormones and Lipid Peroxidation of male Rabbits. J Chem Appl. 3: 908-913.
Copyright: This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Copyright © 2021; Eman, G. A. Allafi
Publication history:
Received date: 04 November, 2021Accepted date: 29 December, 2021
Published date: 06 December, 2021
Abstract
Tramadol manhandle straightforwardly impacts the discharge of luteinizing hormone and follicular stimulating g hormone from the front pituitary organ that diminishes the common discharge of luteinizing hormone in a pulsatile way, resulting in a negative impact on male testiclesdue to lower levels of testosterone hormone. Animals were orally given 40 mg/kg B.W. doses of tramadol. The tried measurements were given to rabbits each other day for 6 weeks. Tramadol significantly decreased body weight (BW), weight of brain, testes, testosterone, estradiol, follicle stimulating hormone (FSH), luteinizing hormone (LH), triiodothyronine (T3) and thyroxin hormone (T4). While, it caused significant increase in thiobarbituric acid-reactive substances (TBARS) concentrations in plasma, testes and brain.
Keywords: Tramadol; Hormone; TBARS; Rabbits
