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Research ArticleDOI Number : 10.36811/jca.2021.110033Article Views : 0Article Downloads : 1
In vitro antimicrobial activity screening of new Heterocyclic compounds derived from 5-bromo-2,3-di(furan-2-yl)-1h-indole
Hana A. A. Mageed1, Reda F. El- Ezabi1 and Fayrouz A. Khaled2*
1Biomedical Science Department, Faculty of pharmacy, Omar Al-Mokhtar University, El -Beida-Libya
2Chemistry Department, Faculty of Science, Omar El – Mukhtar University, Libya
*Corresponding Author: Fayrouz A. Khaled, Chemistry Department, Faculty of Science, Omar El – Mukhtar University, Libya, email: fayalzobair@yahoo.com
Article Information
Aritcle Type: Research Article
Citation: Hana AA Mageed, Reda F El-Ezabi, Fayrouz A Khaled. 2021. In vitro antimicrobial activity screening of new Heterocyclic compounds derived from 5-bromo-2,3-di(furan- 2-yl)-1h-indole. J Chem Appl. 3: 889-893.
Copyright: This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Copyright © 2021; Hana AA Mageed
Publication history:
Received date: 07 October, 2021Accepted date: 29 November, 2021
Published date: 06 December, 2021
Abstract
This article describes the antimicrobial activity evaluation of new heterocyclic compounds derived from 5-bromo-2,3-di(furan-2-yl)-1h-indole. Heterocyclic moiety serve as perfect framework on which pharmacophores can be effectively attached to produce novel drugs. New compounds were obtained on the basis of derivatives including 1H-indole-2,3-dione derivatives. Acid-catalyzed, three-component reaction (Belinelli synthesis) between 5-bromo-2,3-di(furan-2-yl)1H-indole, acetylacetone and semi carbazide, thiosemicarbazone, urea, thiourea, guanidine constitutes a rapid and facile synthesis of corresponding tetrahydro pyrimidines, which are interesting compounds with a potential for pharmaceutical application. Antimicrobial tests revealed high antibacterial activity of obtained derivatives. The synthesized compounds have been screened for their in vitro antimicrobial activity against various strains of bacteria and fungi.
Keywords: Vitro; Heterocyclic Compounds; Antimicrobial
