Welcome to International Journal of Biology and Medicine

Assi Prof. Xiaolun Sun

Affiliation :
University department in Blacksburg, Virginia,China

Biography :

My research interest is to study the complex interplay between bacterial pathogens, microbiome and host

immune system in gastrointestinal tract of chickens and mice. I have dedicated on establishing the mechanism

implicated in food borne bacterial pathogen Campylobacter jejuni-induced intestinal inflammation and poultry

necrotic enteritis. Over the years, I have made several important discoveries in this field of research including

the elucidation of mTOR, PI3K/PI3K?, and NOD2 signaling in controlling campylobacteriosis. In addition, my

work highlighted the key role of immune cells of macrophages and neutrophils in the pathogenesis. My

research reveals the essential role of microbiome protecting against C. jejuni in mice. More recently, I

discovered that microbial metabolite secondary bile acids deoxycholic acid reduces Eimeria maxima and

Clostridium perfringens-induced necrotic enteritis and chicken-transmission-worsened campylobacteriosis.

With the support of this proposal, I will extend these novel findings and significantly contribute to unraveling the

mechanism of microbiome as effective and sustainable antimicrobial free approaches against chicken necrotic

enteritis.

Research Interest :
y overall research interest is to understand the dynamic interaction among host cellular events, molecular signaling, intestinal microbiome, and bacterial pathogens during health and disease and to identify signaling pathways and microbiome which attenuate microbe-mediated intestinal diseases in human and poultry. I employ poultry and murine models to dissect the complex interaction. Specifically, my laboratory focuses on the following areas of biomedical and poultry research: (A) Poultry production, microbiome, and C. jejuni transmission and pathogenesis; (B) Microbiome and host cellular and molecular signaling in microbe-induced intestinal diseases such as necrotic enteritis in poultry and human inflammatory bowel diseases.